Samarium sm 153 lexidronam pentasodium
Quadramet (samarium sm 153 lexidronam pentasodium) is a small molecule pharmaceutical. Samarium sm 153 lexidronam pentasodium was first approved as Quadramet on 1997-03-28. It has been approved in Europe to treat neoplasms and pain.
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19 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 3 | 3 | 1 | — | 1 | 7 |
| Neoplasms | D009369 | — | C80 | 3 | 1 | 1 | — | — | 4 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | 2 | 1 | — | — | 4 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 2 | 1 | — | — | 3 |
| Pain | D010146 | EFO_0003843 | R52 | 2 | 2 | 1 | — | — | 3 |
| Lung neoplasms | D008175 | — | C34.90 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 4 | 3 | — | — | — | 4 |
| Plasma cell neoplasms | D054219 | — | — | 4 | 3 | — | — | — | 4 |
| Plasmacytoma | D010954 | — | C90.3 | 4 | 3 | — | — | — | 4 |
| Osteosarcoma | D012516 | — | — | 2 | 2 | — | — | — | 4 |
| Bone neoplasms | D001859 | EFO_0003820 | D16 | 2 | 1 | — | — | — | 3 |
| Sarcoma | D012509 | — | — | — | 2 | — | — | — | 2 |
| Second primary neoplasms | D016609 | — | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bone nails | D001858 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Castration-resistant prostatic neoplasms | D064129 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Samarium sm 153 lexidronam pentasodium |
| INN | — |
| Description | Samarium (153Sm) lexidronam (chemical name Samarium-153-ethylene diamine tetramethylene phosphonate, abbreviated Samarium-153 EDTMP, trade name Quadramet) is a chelated complex of a radioisotope of the element samarium with EDTMP. It is used to treat pain when cancer has spread to the bone.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 160369-78-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2096660 |
| ChEBI ID | — |
| PubChem CID | 9810246 |
| DrugBank | — |
| UNII ID | — |
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158 adverse events reported
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